In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7627-44-3, name is 2,4-Dichloro-5-(iodomethyl)pyrimidine, the common compound, a new synthetic route is introduced below. SDS of cas: 7627-44-3
To a solution of 2,6-dimethylaniline (3.8 g, 31.4 mmol) and 2,4-dichloro-5- (iodomethyl)pyrimidine (7.0 g, 24.2 mmol) in acetone was added K2CO3 (5.0 g, 36.2 mmol), the mixture was stirred at 50 oC for 6 h. then removed acetone, extracted with ethyl acetate (150 mL × 3), washed with water (80 mL × 2), brine (80 mL× 2), dried with Na2SO4. Purified by silica gel (PE/DCM = 2/1, 1/1, DCM) to give N-((2,4- dichloropyrimidin-5-yl)methyl)-2,6-dimethylaniline as a light yellow solid (4.5 g), yield 66percent. LC/MS (ESI) m/z = 282 (M + H) +.
The synthetic route of 7627-44-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE BROAD INSTITUTE, INC.; DANA-FARBER CANCER INSTITUTE, INC.; THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL; GRAY, Nathanael, S.; LIANG, Yanke; CHOI, Hwan, Geun; SUNDBERG, Thomas; SHAMJI, Alykhan; XAVIER, Ramnik; FISHER, David E.; (251 pag.)WO2018/9544; (2018); A1;,
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