Electric Literature of 2972-52-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2972-52-3, name is 2,4-Dichloro-5-pyrimidinecarbonyl chloride, molecular formula is C5HCl3N2O, molecular weight is 211.43, as common compound, the synthetic route is as follows.
Amberlyst A-21 ion exchange resin (1. 8 g) was added to a solution of 2,4- DICHLOROPYRIMIDINE-5-CARBONYL chloride (18.3 g, 86. 6 mmol) in ethyl acetate (400 mL). More ethyl acetate (50 mL) was added and 2,6-dimethylaniline (10.5 g, 10.7 mL, 86. 6 mmol) was added dropwise at room temperature. The reaction mixture was heated at 50 C overnight then cooled and quenched with water and extracted extracted with ethyl acetate (3 x 100 mL). The organic layer was washed with 1 N HC1 (30 mL), 1 M NaOH (30 mL) and brine (30 mL). The organic layer was then dried on sodium sulfate, filtered and concentrated in vacuo. The crude product was washed with dichloromethane (2 X 30 ML) to afford the title compound as a pale yellow solid NMR (400 MHz, CDC13) : 9. 08 (1H, s), 7.71 (1H, s), 7.15-7. 23 (3H, m), 2.32 (6H, s); 13C NMR (400 MHz, CDC13) : 19.12, 127.56, 128. 78, 129.00, 132.75, 135.81, 158. 61,160. 25,162. 23,162. 41; MS: 296 [M+H+]
Statistics shows that 2972-52-3 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-5-pyrimidinecarbonyl chloride.
Reference:
Patent; AMGEN INC.; WO2005/9443; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia