With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.35265-83-9, name is 2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine, molecular formula is C7H4Cl2N2S, molecular weight is 219.09, as common compound, the synthetic route is as follows.Computed Properties of C7H4Cl2N2S
Reference Example 58 2-Chloro-4-dodecylamino-7-methylthieno[3,2-d]pyrimidine In 1 ml of DMF, 700 mg (3.2 mmol) of 2,4-dichloro-7-methylthieno[ 3,2-d]pyrimidine was dissolved, and then 1.30 g (7.0 mmol) of dodecylamine was added dropwise thereto over 5 minutes. The reaction solution was stirred at 0C. for one hour and then allowed to resume room temperature, followed by stirring for further 1 hour. After completion of the reaction, ice water was added to the reaction mixture, followed by extraction with ethyl acetate (50 ml*3). After the organic layer was washed successively with 1N hydrochloric acid, water and brine and dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure. The residue was purified by silica gel chromatography (eluent: ethyl acetate-hexane={fraction (1/10)}) to give 745 mg (yield: 63.4%) of the title compound. NMR (delta, CDCl3): 0.88 (3H, t, J=7 Hz), 1.26-1.44 (18H, m), 1.65-1.72 (2H, m), 2.42 (3H, s), 3.63-3.68 (2H, m), 4.98 (1H, br), 7.35 (1H, s)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,35265-83-9, 2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; NAKASHIMA, YOSHIHARU; FUJITA, TAKASHI; HIZUKA, MICHIYO; IKAWA, HIROSHI; HIRUMA, TORU; US2001/6969; (2001); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia