Adding a certain compound to certain chemical reactions, such as: 3177-24-0, 2,4-Dichloropyrimidine-5-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2,4-Dichloropyrimidine-5-carbonitrile, blongs to pyrimidines compound. name: 2,4-Dichloropyrimidine-5-carbonitrile
Followingthe preparation protocol of Section 5.1.2.1, the reaction mixtureof 2,4-dichloropyrimidine-5-carbonitrile (8d) (367 mg, 2.0mmol), K2CO3 (552 mg, 4.0 mmol) and phenol (188 mg, 2.0 mmol)in acetone (10 mL) was stirred at room temperature for 7 h to givecompound 9f as a white solid (408 mg, 88.0percent); mp 94?96 C; 1HNMR (400 MHz, Acetone d6) d (ppm) 9.08 (s, 1H), 7.54 (t, J = 7.2Hz, 2H), 7.41?7.35 (m, 3H); HRMS (ESI): m/z, Calcd. for C11H7ON3-Cl [M+H]+: 232.0272, Found 232.0270
At the same time, in my other blogs, there are other synthetic methods of this type of compound,3177-24-0, 2,4-Dichloropyrimidine-5-carbonitrile, and friends who are interested can also refer to it.
Reference:
Article; Cui, Guonan; Jin, Jing; Chen, Hualong; Cao, Ran; Chen, Xiaoguang; Xu, Bailing; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 2186 – 2197;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia