Reference of 1780-40-1 ,Some common heterocyclic compound, 1780-40-1, molecular formula is C4Cl4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
In a 250 mL three-neck flask fitted with a degassing tube and temperature probe, acetonitrile (100 mL) and water (25 mL) were degassed with nitrogen for 30 min while stirring. 2,4,5,6-Tetrachloropyrimidine (8.77 g, 0.0402 mol, 1.5 equiv) and triphenylphosphine (0.70 g, 2.6 mmol, 0.1 equiv) were added and degassed for 15 min. 5-Chloro-2-methoxyphenylboronic acid (5.00 g, 0.0268 mol, 1.0 equiv), potassium phosphate (11.39 g, 0.0536 mol, 2.0 equiv) and palladium acetate (301 mg, 1.3 mmol, 0.05 equiv) were added and degassed for 5 min. The reaction was complete after 2 h at room temperature. The reaction mixture was added to 250 mL CH2Cl2. The organic layer was washed twice with water (125 mL), dried over Na2SO4, and concentrated. The crude product was purified by silica gel column chromatography. The product was obtained as a white solid (5.97 g, 69%). 1H NMR (500 MHz, CDCl3, delta): 7.45 (dd, J=8.9, 2.6 Hz, 1H), 7.31 (d, J=2.6 Hz, 1H), 6.94 (d, J=8.9 Hz, 1H), 3.82 (s, 3H); MS (ESI+): calculated for C11H6Cl4N2O, 321.92; m/z found, 323.0 [M+H+].
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1780-40-1, 2,4,5,6-Tetrachloropyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Fitzgerald, Anne E.; Liu, Jing; Mani, Neelakandha S.; US2009/76268; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia