In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55583-59-0, name is 2,5-Diamino-4,6-dichloropyrimidine, the common compound, a new synthetic route is introduced below. Formula: C4H4Cl2N4
In the reaction vessel, 4,6-dichloropyrimidine-2,5-diamine(501 mg, 2.79 mmol),Benzofuran-2-boronic acid (1.05 g, 6.46 mmol),Sodium carbonate (1.48 g, 14.0 mmol),And tetrakis (triphenylphosphine) palladium (0)To a solution of (161 mg, 0.140 mmol) in toluene (28 mL), ethanol (7 mL) and distilled water (7 mL) are added at room temperature, and the reaction solution is stirred under an argon atmosphere for 20 hours under heat reflux Was cooled to room temperature. Add distilled water (8 mL) and stir,The separated aqueous layer was extracted three times with ethyl acetate (12 mL).Thereafter, the whole organic layer is combined, saturated aqueous sodium chloride solution (12 mL) is added thereto, the mixture is stirred and washed, anhydrous sodium sulfate is added to the separated organic layer for dehydration, and the filtrate after filtration is concentrated under reduced pressure. Flash column chromatography of the obtained concentratePurified with (silica gel, n-hexane / ethyl acetate),4,6-Di (benzofuran-2-yl) pyrimidine-2, 5-diamine(0.748 g, 78% yield)
The synthetic route of 55583-59-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Microbial Chemistry Research Foundation; Kumagai, Naoya; Noda, Hidetoshi; Asada, Yasuko; Shibazaki, Masakatsu; (48 pag.)JP2019/64981; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
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