Adding a certain compound to certain chemical reactions, such as: 55583-59-0, 2,5-Diamino-4,6-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C4H4Cl2N4, blongs to pyrimidines compound. Formula: C4H4Cl2N4
In the reaction vessel, 4,6-dichloropyrimidine-2,5-diamine(500 mg, 2.79 mmol), 3-thienylboronic acid(0.821 g, 6.42 mmol), sodium carbonate(1.48 g, 14.0 mmol), and tetrakis (triphenylphosphine) palladium (0) (162 mg, 0.140 mmol) in toluene (28 mL) in ethanol (7 mL),And distilled water (7 mL) were added at room temperature, and the reaction solution was cooled to room temperature after stirring for 20 hours under heating reflux conditions under an argon atmosphere.Add distilled water (8 mL), stir, separate the aqueous layer with ethyl acetateIt extracted 3 times with (12 mL). After that, combine all organic layers,Saturated aqueous sodium chloride solution (12 mL) is added thereto, and the mixture is stirred for washing, and the separated organic layer is dried over anhydrous sodium sulfate.The filtrate after filtration was concentrated under reduced pressure. The concentrate thus obtained is purified by flash column chromatography (silica gel, n-hexane / ethyl acetate),4,6-di (thiophen-3-yl) pyrimidine-2,5-diamine(0.737 g, 96% yield).
The synthetic route of 55583-59-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Microbial Chemistry Research Foundation; Kumagai, Naoya; Noda, Hidetoshi; Asada, Yasuko; Shibazaki, Masakatsu; (48 pag.)JP2019/64981; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia