Adding a certain compound to certain chemical reactions, such as: 55583-59-0, 2,5-Diamino-4,6-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 55583-59-0, blongs to pyrimidines compound. SDS of cas: 55583-59-0
General procedure: To a solution of pyrimidine (100 mg, 1 equivalent) in anhydrous dioxane (2 mL/mmol) under argon atmosphere, were successively added the amine (1 equivalent) and APTS.H2O (0.5 equivalent). The solution was stirred at reflux for 6h and then allowed to reach room temperature. A 0.2 M solution of corresponding dimethyliminium chloride (2 to 3 equivalents) in anhydrous DMF, or a 0.2 M solution of POCl3 or oxalyl chloride (1.5 to 3 equivalents) in corresponding N,N-dimethylamide was then added dropwise and the resulting mixture was stirred for another hour. Water (5 mL/mmol) was then slowly added and the resulting mixture was stirred at room temperature for 18h. The solution was diluted in AcOEt (5 mL/mmol) and washed with a saturated aqueous solution of NaHC03 (5 mL/mmol). The aqueous layer was extracted 3 times with AcOEt and the resulting organic layer was then dried over magnesium sulfate. After concentration under reduced pressure, the crude product was purified by chromatography on silica gel to afford the pure compound.
The synthetic route of 55583-59-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UNIVERSITE GRENOBLE ALPES; DECOUT, Jean-Luc; ZELLI, Renaud; ZEINYEH, Wael; BOUCHERLE, Benjamin; HAUDECOEUR, Romain; (53 pag.)WO2018/203099; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
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