As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 28969-60-0, name is 2,5,6-Trichloropyrimidin-4-amine, molecular formula is C4H2Cl3N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C4H2Cl3N3
EXAMPLE 1 This example illustrates the preparation of 4(2,3,5,6-tetrafluoro-4-trifluoromethylanilino)2,5,6-trichloropyrimidine (Comound No. 6 of Table I) having the formula: SPC1 4-Amino-2,5,6-trichloropyrimidine (1.98 g) was dissolved in dry dimethylformamide (25 cc) and the solution added dropwise to a stirred suspension of sodium hydride (0.5 g) in dry dimethylformamide (25 cc) under a nitrogen atmosphere at 0C. When the addition was complete and evolution of hydrogen had ceased a solution of octafluorotoluene (2.4 g) in dry dimethylformamide (15 cc) was added dropwise to the mixture at 0C. When this addition was complete the mixture was stirred for 30 minutes, and the temperature allowed to rise to 21C. The mixture was then poured into a mixture of iced water and salt (400 cc) and acidified with dilute hydrochloric acid. The gummy precipitate which was formed slowly hardened on standing (18 hours) and was twice recrystallized from a mixture of methylene chloride and petroleum ether (boiling range 40-60C) to yield 4(2,3,5,6-tetrafluoro-4-trifluoromethylanilino)-2,5,6-trichloropyrimidine, having a melting point of 152.4 to 153C.
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Reference:
Patent; Imperial Chemical Industries Limited; US3974276; (1976); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia