Application of 26032-72-4, Adding some certain compound to certain chemical reactions, such as: 26032-72-4, name is 2,4-Dichloro-6-phenylpyrimidine,molecular formula is C10H6Cl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26032-72-4.
The compound 2,4-dichloro-6-phenylpyrimidine (1.52 g, 6.7 mmol),(+/-)-trans-3-aminobicyclo[2.2.2]octane-2-carboxylic acid methyl ester(1.84 g, 10.0 mmol) was dissolved in N,N-dimethylformamide (10 mL).Potassium carbonate (0.92 g, 6.7 mmol) was then added to the reaction mixture.The resulting mixture was stirred at room temperature overnight. After the reaction is complete,It was diluted with H2O (50 mL), and the mixture was extracted with ethyl acetate (40mL×3).The combined organic phases were washed with saturated brine (50 mL).Dry with anhydrous sodium sulfate, filter, and concentrate the filtrate under reduced pressure.The residue was purified by silica gel column chromatography(n-hexane/ethyl acetate (v/v) = 20/1-10/1)The title compound was obtained as a white solid(1.65g, 66%).
According to the analysis of related databases, 26032-72-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Tang Changhua; Yin Junjun; Yi Kai; Lei Yibo; Wang Yejun; Zhang Yingjun; (138 pag.)CN108276401; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
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