Synthetic Route of 287714-35-6, Adding some certain compound to certain chemical reactions, such as: 287714-35-6, name is Methyl 2-chloropyrimidine-5-carboxylate,molecular formula is C6H5ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 287714-35-6.
To a stirred solution of methyl 2-chloropyrimidine-5-carboxylate (5 g, 28.97 mmol) in dry DMF (60 mL), TEA (12.09 mL, 86.92 mmol) and tert-butyl piperazine-1-carboxylate (5.93 g, 31.87 mmol) were added at 0 C. The reaction mixture was heated at 100 C overnight. Itwas concentrated to half of the volume and filtered. The resulting solid was dissolved inDCM (35 mL) and washed with water (20 mL), dried over Na2SO4 and concentratedaffording the title product. Yield: 70% (7 g, off white solid). 1H NMR (400 MHz, DMSO-d6):6 8.81 (5, 2H), 3.84 (t, J = 4.8 Hz, 4H), 8.80 (5, 3H), 3.48-3.38 (m, 4H), 1.42 (5, 9H). LCMS:(Method A) 323.3 (M+H), Rt. 4.31 mm, 99.89% (Max).
According to the analysis of related databases, 287714-35-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut, Gajendra; (280 pag.)WO2017/144633; (2017); A1;,
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