Analyzing the synthesis route of 289042-12-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,289042-12-2, its application will become more common.

289042-12-2, Adding a certain compound to certain chemical reactions, such as: 289042-12-2, tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 289042-12-2, blongs to pyrimidines compound.

BEM (20.0g) was dissolved in acetonitrile (140ml) at 40C, then cooled to 35C beforegradual addition of hydrochloric acid (0.02M, 35ml) at 35C. The resulting solution wasstirred at 35C until the reaction was complete then cooled to 25C. Sodium hydroxide(l.OM, 38ml) was added at 25C and the resulting mixture stirred at this temperature until thereaction was complete. Aqueous hydrochloric acid (1M) was added to adjust the pH of thesolution to pH9. The solution was distilled under reduced pressure (52mBar, <40C) untilapproximately 100ml of acetonitrile/water had been removed. Water (100ml) was added anddistillation continued until a further 100ml of acetonitrile/water had been removed. Theresulting mixture was filtered through a filter pad, the filter washed with water (30ml) and thefiltrates heated to 40C before addition of a solution of calcium chloride dihydrate (3.07g) inwater (29.5ml) over 20min, maintaining the reaction mixture at 38-41C.The reaction mixture was stirred for a further ISmin at 40C, then cooled to 20C and stirredat this temperature for a further 15min. The resulting suspension was filtered, washed withwater (3 x 50ml) and dried to give (?')-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3/?,55')-3,5-dihydroxyhept-6-enoic acidcalcium salt (15.8g, 84% yield). These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,289042-12-2, its application will become more common. Reference:
Patent; ASTRAZENECA UK LIMITED; WO2004/108691; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia