Synthetic Route of 2915-16-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine, molecular formula is C16H11ClN2, molecular weight is 266.73, as common compound, the synthetic route is as follows.
TP2 is further reacted with 2-chloro-4,6-diphenylpyrimidine (1.0 equivalents, CAS: 2915-16-4), tris(dibenzylideneacetone)dipalladium(0) (Pd2(dba)3 (0.03 equivalents; CAS 51364-51 -3), Tricyclohexylphosphine (PCy3; 0.07 equivalents, CAS 2622-14-2) and potassium phosphate tribasic (K3PO4, 1 .7 equivalents). The reaction mixture is stirred under nitrogen atmosphere in a dioxane/toluen e/water (6/1/1 ) mixture at 100 C overnight. After cooling down to room temperature (RT) the reaction mixture is extracted with DCM/brine. The organic phases are collected, washed with brine and dried over MgS04. The organic solvent is removed, the crude product was washed with cyclohexane and recrystallized from EtOH (Yield: 98%).
Statistics shows that 2915-16-4 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-4,6-diphenylpyrimidine.
Reference:
Patent; CYNORA GMBH; SZAFRANOWSKA, Barbara; PINGEL, Patrick; BERGMANN, Larissa; AMBROSEK, David; KASPAREK, Christian; (0 pag.)WO2019/162332; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
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