Reference of 1032452-86-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole, molecular formula is C13H10ClN3, molecular weight is 243.69, as common compound, the synthetic route is as follows.
Compound 1-(7-amino-6-methoxy-3,4-dihydroquinolin-1(2H)-yl)prop-2-en-1-one (0.22 g, .95 mmol),3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole (0.19 g, 0.79 mmol)And p-chlorobenzoic acid (0.16g, 0.95mmol)In a two-necked flask,The reaction was carried out by adding 1,4-dioxane (6 mL) and heating to 90C.Check the progress of the reaction through the TLC point plate,About 5 hours after the reaction is completed,After processing,To room temperature,Add 25% aqueous ammonia (0.2 mL) and water (0.97 mL) to quench,Desolvent,Purification by column chromatographyThe product was obtained (83 mg, yield 24.0%).
The chemical industry reduces the impact on the environment during synthesis 1032452-86-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Tianjin Binjiang Pharmaceutical Research And Development Co., Ltd.; Tian Hongqi; Huang Gongchao; Cheng Ying; (48 pag.)CN107793413; (2018); A;,
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