Synthetic Route of 38275-43-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 38275-43-3, name is 2-(Methylthio)pyrimidine-5-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows.
Step 3 2-{[(1-{[(1R,2R)-2-Phenylcyclopropyl]carbonyl}piperidin-4-yl)methyl]amino}pyrimidine-5-carbonitrile A mixture of (1-{[(1R,2R)-2-phenylcyclopropyl] carbonyl}piperidin-4-yl)methylamine (EXAMPLE 153, STEP 2) (0.100 g, 0.387 mmol), 2-(methylthio)pyrimidine-5-carbonitrile (0.059 g, 0.387 mmol) and cesium carbonate (0.252 g, 0.774 mmol) in DMF (1 mL) was heated at 70 C. for 1 h. The reaction mixture was cooled to RT, diluted with ethyl acetate (5 mL), washed with water (5*10 mL), and brine (10 mL), then dried over Na2SO4, filtered and concentrated. The residue was chromatographed on a reversed phase column, running 5-95% 0.1%TFA in CH3CN/0.1%TFA in water to give the title compound as a TFA salt. M.S. (M+1): 362. 1H NMR (400 MHz, CDCl3): delta8.52 (s, 1 H, Pyr), 8.45 (s, 1 H, Pyr), 7.28 (t, J=7.9 Hz, 2 H, Ar), 7.20 (t, J=6.6 Hz, 1 H, Ar), 7.11 (d, J=7.3 Hz, 2 H, Ar), 5.78 (s, 1 H, NH), 4.66 (d, J=12.2 Hz, 1 H, NCH2), 4.15 (d, J=13.1 Hz, 1 H, NCH2), 3.41 (m, 2 H, NHCH2), 3.06 (q, J=12.4 Hz, 1 H, NCH2), 2.62 (t, J=12.7 Hz, 1 H, NCH2), 2.47 (brs, 1 H, ArCH), 1.96 (m, 1 H, CHCO), 1.91 (m, 1 H, CH2CHCH2), 1.80 (d, J=13.2 Hz, 2 H, CHCH2CH2), 1.65 (s, 1 H, CHCH2CH), 1.27 (s, 1 H, CHCH2CH), 1.25 (m, 2 H, CHCH2CH2).
According to the analysis of related databases, 38275-43-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Claiborne, Christopher F.; Butcher, John W.; Claremon, David A.; Libby, Brian E.; Liverton, Nigel J.; Munson, Peter M.; Nguyen, Kevin T.; Phillips, Brian; Thompson, Wayne; McCauley, John A.; US2002/165241; (2002); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia