Application of 3932-97-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3932-97-6 as follows.
Step 1: To a solution of 60_1 (2.00 g, 9.22 mmol, 1.00 eq) in THF (40 mL) was added ZnCi2-Et20 (1 M, 11.06 mL, 1.20 eq) at 0C under nitrogen protection. The mixture was stirred for 2 hours at 0C. Methylsulfanylsodium (646.23 mg, 9.22 mmol, 02429524H5-01 – TO SS?.48 muL·, 1.00 eq) was added. The resulting mixture was stirred at 20C for 16 hours. TLC (pure PE) showed reactant 1 (Rf=0.5) consumed and product (Rf=0.3) formed. The mixture was quenched with 1M HC1 (20 mL) and concentrated. The aqueous layer was extracted with DCM (20 mL*3). The combined organic layer was concentrated and purified by silica gel column (PE: EA=1 :0~50: 1) to give 60_2 (1.00 g, 1.97 mmol, 21.4% yield, 45.1% purity) as colorless oil. LCMS: RT = 0.794 min, mlz 228.9 [M+H]+ NMR (CDC13, 400 MHz) delta 8.67 (s, 1H), 2.62 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3932-97-6, its application will become more common.
Reference:
Patent; YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD; BEN NERIAH, Yinon; BRACHYA, Guy; BURSTAIN, Ido; MINZEL, Waleed; SNIR-ALKALAY, Irit; VACCA, Joseph; LI, Dansu; (129 pag.)WO2017/21969; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia