Electric Literature of 607740-08-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 607740-08-9, name is 4-(3,5-Dibromophenyl)-2,6-diphenylpyrimidine, molecular formula is C22H14Br2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(3) Synthesis of Compound (A98)Intermediate Compound (K) in an amount of 3.0 g (6 mmoles), 2.3 g (14 mmoles) of carbazole, 0.12 g (0.6 mmoles) of copper iodide and 4.2 g (20 mmoles) of potassium phosphate were suspended into 21 ml of 1,4-dioxane. To the obtained suspension, 0.8 ml (6 mmoles) of trans-1,2-cyclohexanediamine was added. Under the atmosphere of argon, the resultant mixture was heated for 18 hours under the refluxing condition. The reaction solution was then cooled at the room temperature. Methylene chloride and water were added and the resultant mixture was separated into two layers. The organic layer was washed with water and dried with anhydrous sodium sulfate. After the organic solvent was removed by distillation under a reduced pressure, the residue of distillation was suspended into 21 ml of dioxane. To the obtained suspension, 0.12 g (0.6 mmoles) of copper iodide, 2.9 g (14 mmoles) of potassium phosphate and 0.8 ml (6 mmoles) of trans-1,2-cyclohexanediamine were added. Under the atmosphere of argon, the resultant mixture was heated for 18 hours under the refluxing condition. The reaction solution was then cooled at the room temperature. Methylene chloride and water were added and the resultant mixture was separated into two layers. The organic layer was washed with water and dried with anhydrous sodium sulfate. After the organic solvent was removed by distillation under a reduced pressure, 30 ml of ethyl acetate was added. The formed crystals were separated by filtration and washed with ethyl acetate and 3.3 g (the yield: 80%) of yellowish white crystals were obtained. It was confirmed by 90 MHz 1H-NMR and FD-MS that the obtained crystals were the target substance (A98). The result of the measurement by FD-MS is shown in the following:FD-MS calcd. for C46H30N4=638; found: m/z=638 (M+, 100)
According to the analysis of related databases, 607740-08-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Idemitsu Kosan Co., Ltd.; US2012/319099; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia