Related Products of 58536-46-2 ,Some common heterocyclic compound, 58536-46-2, molecular formula is C22H15BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
11.9 g (34 mmol) of 4-(4-bromophenyl)-2,6-diphenylpyrimidine are dissolved in 300 ml of THF and subsequently cooled to -100 C. 22 ml (38 mmol) of a 1.6M solution of n-butyllithium in hexane are slowly added dropwise to the reaction mixture with stirring. The reaction mixture is stirred for 30 min. 200 ml (34 mmol) of a solution of 2-bromo-1,3-diphenyl-2,3-dihydro-1H-benzo-1,3,2-diazaborole in toluene are subsequently added dropwise. The reaction mixture is warmed to 0 C. over a period of 4 h, then 600 ml of ethanol are added dropwise. The precipitated solid is recrystallised from toluene and subsequently sublimed. Yield: 11 g (60% of theory, purity >99.9%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 58536-46-2, 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Merck Patent GmbH; Mujica-Fernaud, Teresa; Parham, Amir Hossain; Stoessel, Philipp; Pflumm, Christof; Buesing, Arne; Eberle, Thomas; (30 pag.)US10032992; (2018); B2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia