Reference of 3435-25-4 , The common heterocyclic compound, 3435-25-4, name is 4-Chloro-6-methylpyrimidine, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
BA-1 (1.00 g, 7.78 mmol) and Ni(dppe)Cl2 (82 mg, 0.16 mmol)The solution in anhydrous Et 2 O (5 mL) was cooled to -10 C.A solution of cyclopropylmagnesium bromide (1.36 g, 8.56 mmol) was added dropwise and the mixture was stirred at -10 C for 2 h.The mixture was quenched with saturated aqueous NH4CI, extracted with DCM and concentrated. The crude BD-1 can continue to be used without further processing.
The synthetic route of 3435-25-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BAKONYI,JOHANNA; BRUNETTE,STEVEN RICHARD; COLLIN,DELPHINE; HUGHES,ROBERT OWEN; LI,XIANG; LIANG,SHUANG; SIBLEY,ROBERT; TURNER,MICHAEL ROBERT; WU,LIFEN; ZHANG,QIANG; (169 pag.)TW2018/38997; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
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