With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.24391-41-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, molecular formula is C7H3ClN4, molecular weight is 178.58, as common compound, the synthetic route is as follows.Quality Control of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
Step 13-3 (5)-4-(2-(7-fiuoro-4-oxo-3,4-dihydropyrrolo[l,2-f][l,2,4]triazin-2-yl) pyrrolidin- 1 -yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (106) Compound 106 A mixture of 13b (0.16 mmol), 4-chloro-7H-pyrrolo[2,3-d]pyrimidine- 5-carbonitrile (28 mg, 0.16 mmol) and TEA (0.08 mL, 0.58 mmol) in n-BuOH (5 mL) was stirred at reflux for 2 hours. The reaction mixture was concentrated and purified by flash column chromatography eluting with MeOH/water to afford Compound 106 as a white solid (27 mg, yield: 62%). MS (m/z): 364.7 (M+H)+. 1H NMR (400 MHz, DMSO-d6) delta: 13.07-12.72 (m, 1H), 11.76 (s, 1H), 8.30 (s, 1H), 8.13 (s, 1H), 6.81-6.73 (m, 1H), 6.31-6.09 (m, 1H), 5.15-5.07 (m, 1H), 4.32-4.24 (m, 1H), 3.96-3.92 (m, 1H), 2.40-2.30 (m, 1H), 2.18-2.02 (m, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,24391-41-1, 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DAI, Guangxiu; XIAO, Kun; JIA, Hong; VENABLE, Jennifer Diane; BEMBENEK, Scott Damian; WO2014/15675; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia