Application of 199678-12-1 ,Some common heterocyclic compound, 199678-12-1, molecular formula is C11H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Under an argon atmosphere, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (1.87 g, 9.76 mmol) and dimethylaminopyridine (2.48 g, 20.3 mmol) were added to a solution of compound 18 (2.00 g, 8.13 mmol) and 4-pyrimidin-2-ylbenzoic acid (2.00 g, 10.0 mmol) in dehydrated N,N-dimethylformamide (30 mL) at 0 C. The reaction mixture was left to stand overnight, then poured into ice water and stirred for 0.5 h at 0 C. The precipitate was collected by filtration and dissolved in ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated to afford 2.80 g (88%) of the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6) delta 9.14 (t, J = 5.6 Hz, 1H), 8.94 (d, J = 4.8 Hz, 2H), 8.49 (d, J = 8.8 Hz, 2H), 8.17 (dd, J = 9.2, 2.8 Hz, 1H), 8.07-8.04 (m, 3H), 7.49 (t, J = 4.8 Hz, 1H), 7.22 (d, J = 8.8 Hz, 1H), 4.52 (d, J = 5.6 Hz, 2H), 4.14 (t, J = 6.4 Hz, 2H), 1.84 – 1.75 (m, 2H), 1.01 (t, J = 7.4 Hz, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 199678-12-1, 4-Pyrimidin-2-yl-benzoic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Ohashi, Masao; Gamo, Kanae; Tanaka, Yuta; Waki, Minoru; Beniyama, Yoko; Matsuno, Kenji; Wada, Jun; Tenta, Masafumi; Eguchi, Jun; Makishima, Makoto; Matsuura, Nobuyasu; Oyama, Takuji; Miyachi, Hiroyuki; European Journal of Medicinal Chemistry; vol. 90; (2015); p. 53 – 67;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia