Reference of 40497-30-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 40497-30-1, name is 2-Methylpyrimidine-4,6(1H,5H)-dione. A new synthetic method of this compound is introduced below.
4,6-dichloro-2-methylpyrimidine (1.63 g, 10.0 mmol) prepared based on the method described in Production Example 2A above using 2-methyl-1H-pyrimidine-4,6-dione instead of the 2-ethyl-1H-pyrimidine-4,6-dione, was slowly added to a 2-ethoxyethanol (5.0 mL) solution of 3-aminophenol (1.09 g, 10.0 mmol) and the reaction mixture heated for 4 hours at 130C. The reaction was monitored by thin layer chromatography and, following the end of the reaction, the reaction mixture was cooled to room temperature and the precipitated white powder filtered off. The crude product filtered off was used in the subsequent reaction without further purification (1.76 g, crude yield 75%).1H NMR spectrum (DMSO, 400 MHz), delta : 2.42(3H, s), 6.50(1H, m), 6.73(1H, s), 7.05(1H, m), 7.12(1H, m), 7.19(1H, s), 10.00(1H, s). Mass spectrum (EI), m/z: 234 (M-H+)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,40497-30-1, its application will become more common.
Reference:
Patent; Sankyo Company, Limited; EP1473289; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia