Adding a certain compound to certain chemical reactions, such as: 4270-27-3, 6-Chloropyrimidine-2,4(1H,3H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 6-Chloropyrimidine-2,4(1H,3H)-dione, blongs to pyrimidines compound. Recommanded Product: 6-Chloropyrimidine-2,4(1H,3H)-dione
4-Dimethylamino-l-aminoindan (8.5g, 48.2 ?unol) and 6- chlorouracil (3.55g, 24.2 mmol) were dissolved in DMSO (8.5 ml) , heated to 1150C and stirred for 4h. The reaction mixture was cooled to 800C and glyme (ethylene glycol dimethylether) was added to provide a thick mixture which was further refluxed for Ih. The mixture was cooled to room temperature, and the solid collected by filtration and washed well with glyme. The white solid was treated with water (50 ml) and the suspension was refluxed for 30 min, cooled to room temperature, filtered and washed thoroughly with Et2O. A white solid (4g, 58%) was provided. The free base was converted to the HCl salt by dissolving it in EtOH (32 ml) and HCl/EtOH (28% solution, 2.5 ml) and adding Et2O (70 ml) . The salt was ; cdeltalectec TSy rl”‘tfrat&n, washealpha8 with Et2O and dried to give an off-white powder (4.8g, 58%). Mp 192-193C. 1H-NMR (free base) DMSO-d6 delta :10.24 (br epsilon, IH, CONHCO), 9.68 (br s, IH, CONHC), 7.15 (br t, IH, J = 8 Hz, Ar), 6.85 and 6.78 (two br d, 2H, Ar), 6.42 (br d, IH, J = 6 Hz , CHNH), 4.87 (br q, IH, J = 7 Hz , CHNH), 4.64 (br s, IH, CCHCO), 2.75 -2.90 (br s & br m, 8H, Me2N S- CH2CH2C), 2.45 and 1.76 (m, 2H, CHCH2); 13C (free base) DMS0-ds delta : 164.27 (CHCO), 153.70 (NHCNH), 150.72 (NHCONH), 149.80 (Me2NC), 144.03, 133.59, 127.61, 116.0, 115.39, 73.27 (CHCO), 56.64 (CHNH), 42.37 (Me2N), 33.21, 29.41; Anal, (calcd for Ci5Hi8N4O2) C 62.92, H 6.34, N 19.57. Found C 62.73, H 6.45, N 19.20; MS (CI) (iBu) m/z (286.11, M); HRMS (CI, iBu) exact mass calcd for Ci5H18N4O2 286.1429, found 286.1450. 1H-NMR (HCl salt) DMS0-d6 delta: 10.38 (br s, IH, CONHCO), 10.27 (br s, IH, CONHC), 7.64 (br d, IH, J = 8 Hz, Ar), 7.45 and 7.39 (br t & br d, 2H, Ar), 7.20 (br d, IH, J = 6 Hz, CHNH), 5.00 (br q, IH, J = 7 Hz, CHNH), 4.74 (br s, IH, CCHCO), 3.35 (br m, IH, CH2CH2C), 3.0-3.12 (br s & m, 7H, Me2N & CH2CH2C), 2.57 and 1.85 (two m, 2H, CHCH2); 13C (HCl salt) DMSO-d6 delta : 164.26 (CHCO), 154.13 (NHCNH), 150.37 (Me2NC), 145.90 (NHCONH), 140.07, 135.55, 128.65, 124.39, 119.64, 73.09 (CHCO), 56.39 (CHNH), 44.78 (Me2N), 32.87, 28.29; MS (CI) (NH3) m/z (287, MH+) .
At the same time, in my other blogs, there are other synthetic methods of this type of compound,4270-27-3, 6-Chloropyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.
Reference:
Patent; TEVA PHARMACEUTICAL INDUSTRIES, LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2006/20070; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia