Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4316-93-2, name is 4,6-Dichloro-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4316-93-2
Sodium methoxide (2.70 g, 50.0 mmol) was added portionwise over 10 min to a 0C suspension OF 4, 6-DICHLORO-5-NITROPYRIMIDINE (4.85 g, 25.0 mmol) in methanol (90 ml). On complete addition the mixture was stirred at 0C for 2 h. The precipitate was filtered and the filtrate evaporated. The residue was suspended in isohexane and filtered. The filtrate was evaporated and the residue purified by flash column chromatography on silica, eluting with 5% ethyl acetate in isohexane. Collecting appropriate fractions gave 4-chloro-6-methoxy-5- nitropyrimidine (3.50 g, 74%) as a white solid
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Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2004/41826; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia