Synthetic Route of 4316-94-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4316-94-3, name is 6-Chloro-5-nitropyrimidin-4-amine, molecular formula is C4H3ClN4O2, molecular weight is 174.55, as common compound, the synthetic route is as follows.
General procedure: 6-Chloro-5-nitropyrimidine-4-amine (0.5mmol), amine (1.5mmol), Pd2(dba)3 (0.01mmol), R-BINAP (0.03mmol) and potassium carbonate (0.7mmol) were dissolved in acetonitrile (5mL). The solution was stirred at room temperature for 3.5h under an argon atmosphere. The resulting reaction mixture was treated with saturated brines (50mL) and extracted with acetonitrile (3¡Á25mL), and dried with anhydrous Na2SO4. The anhydrous Na2SO4 was removed by filtration and the filtrate was concentrated. The residue was washed with ethyl acetate (3¡Á2mL) and diethyl ether (3¡Á2mL), filtered and dried under vacuum.
The chemical industry reduces the impact on the environment during synthesis 4316-94-3, I believe this compound will play a more active role in future production and life.
Reference:
Article; Liu, Meng-Meng; Mei, Qiong; Zhang, Yi-Xiao; Bai, Peng; Guo, Xiang-Hai; Chinese Chemical Letters; vol. 28; 3; (2017); p. 583 – 587;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia