Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 105742-66-3, name is 4,5-Dichloro-2,6-dimethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C6H6Cl2N2
General procedure: Compound 5 was synthesized as described.33 Compounds 6 and 7were synthesized in our previous work.34 Compounds 4 (5 mmol), 7(5 mmol) and anhydrous potassium carbonate (5 mmol, 0.69 g) wereadded to a mixed solvent of dimethyl formamide (20 mL) and water(10 mL), and then refluxed for 2-4 h. The progress was monitored byTLC. After the reaction was complete, the reaction solution was pouredinto saturated saline and extracted with ethyl acetate (3¡Á80 mL). Theextract was dried, filtered, and the solvent was removed under reducedpressure to give a crude product. Recrystallization from the mixedsolvent of petroleum ether and ethyl acetate gave pure target compoundsO1-17 (Scheme 2). The yields, physical properties, and 1HNMR, GC/HPLC-MS, elemental analyses of the target compounds are asfollows:Data for O1: yield, 75%; purity, 95.5%; yellow solid; mp,101.9-103.9 C. 1H NMR (CDCl3) delta 2.450 (s, 3H, CH3), 2.531 (s, 3H,CH3), 4.663 (q, J=0.6 Hz, 2H, CH2), 5.899 (s, 1H, NH), 7.443-7.491(m, 3H, Ph H), 7.664 (t, J=0.9 Hz, 1H, oxzole H), 8.003-8.049 (m, 2H,Ph H); GC-MS M+=314, base peak 182. Anal. Calcd(%) forC16H15ClN4O: C, 61.05; H, 4.80; N, 17.80. Found: C, 61.07; H, 4.79; N,17.83.
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Reference:
Article; Yan, Zhongzhong; Liu, Aiping; Ou, Yingcan; Li, Jianming; Yi; Zhang, Ning; Liu, Minhua; Huang, Lu; Ren, Jianwei; Liu, Weidong; Hu, Aixi; Bioorganic and Medicinal Chemistry; vol. 27; 15; (2019); p. 3218 – 3228;,
Pyrimidine | C4H4N2 – PubChem,
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