Application of 4562-27-0 ,Some common heterocyclic compound, 4562-27-0, molecular formula is C4H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A solution of bromine (1.0 mL, 20 mmol) in glacial acetic acid (10 mL) was added over 15 min via cannula to a solution of 4-pyrimidone (1.9 g, 20 mmol) in glacial acetic acid (20 mL). After stirring for 5 h, the mixture was filtered and the cake was washed with hexane (2 x 20 mL) to furnish the title compound as a white solid (1.52 g).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4562-27-0, Pyrimidin-4(3H)-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; McDONALD, Edward; BLAGG, Julian; PICHOWICZ, Mark; CRUMPLER, Simon Ross; WO2010/41054; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia