4595-59-9 , The common heterocyclic compound, 4595-59-9, name is 5-Bromopyrimidine, molecular formula is C4H3BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: In a 5 mL flask, aryl halide (1 mmol), alkyl halide (1.1 mmol),thiourea (91 mg, 1.2 mmol), CuFe2O4(12 mg, 5 mol%), K2CO3(552 mg, 4.0 mmol), H2O (0.3 mL), and PEG (2 mL) were added and stirred at 80-100C for the appropriate reaction time. After completion of reaction, the mixture was cooled to room temperature and washed with 5 mL H2O and 10 mL EtOAc. Then,after separation and evaporation of organic solvent, the crude thioethers, were purified by flash column chromatography on silica gel eluted with the appropriate mixture of (EtOAc/n-hexane).
According to the analysis of related databases, 4595-59-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Gholinejad, Mohammad; Karimi, Babak; Mansouri, Fariborz; Journal of Molecular Catalysis A: Chemical; vol. 386; (2014); p. 20 – 27;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia