Adding a certain compound to certain chemical reactions, such as: 1074-40-4, 4,6-Dichloro-2-methoxypyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4,6-Dichloro-2-methoxypyrimidine, blongs to pyrimidines compound. Recommanded Product: 4,6-Dichloro-2-methoxypyrimidine
To a solution of 5-methyl-6-(1-(oxetan-3-yl)piperidin-4-yl)-1 H-indazole (200 mg, 0.74 mmol) and 4,6-dichloro-2-methoxypyrimidinein (132 mg, 0.74 mmol) in DMF (30 mL)was added Cs2CO3 (720 mg, 2.21 mmcl). The reaction mixture was stirred at 50C for 2 h. The resulting mixture was diluted with water (100 mL) and extracted with EtOAc (2 x 100 mL). Thecombined organic layer was washed with water (3 x 100 mL) and brine (100 mL), dried over anhydrous Na2SO4, filtered and concentrated to give a residue. The residue was purified by silica gel column chromatography (PE:EtOAc = 1:2)to give the title compound (120 mg, yield: 40%) as a white solid.LC-MS [mobile phase: from 50% water (0.1% FA) and 50% ACN (0.1% FA) to 5% water (0.1%FA) and 95% ACN (0.1% FA) in 2.6 mm]: Rt = 0.801 mm; MS Calcd: 413, MS Found: 414 [M+ H].
The synthetic route of 1074-40-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DING, Xiao; REN, Feng; SANG, Yingxia; XING, Weiqiang; ZHAN, Yang; ZHAO, Baowei; (357 pag.)WO2018/137593; (2018); A1;,
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