Related Products of 313339-35-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 313339-35-4, name is 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid. A new synthetic method of this compound is introduced below.
Example 2D4,6-dichloro-2-(methylthio)pyrimidine-5-carboxamide; A mixture of the product of Example 2C (5 g, 20.9 mmol) in thionyl chloride (10 mL) was refluxed for 1 hour. After cooling to ambient temperature, the mixture was concentrated in vacuo. Tetrahydrofuran (50 mL) was added, followed by 25% aqueous ammonia (1.6 mL) at 0″C and the mixture was stirred at ambient temperature for 2 hours. Dichloromethane (100 mL) was added and the organic layer was washed with saturated aqueous sodium bicarbonate and brine, dried over sodium sulfate, filtered, and concentrated in vacuo. The crude solid was washed with petroleum ether to give the title compound. MS: 238 (M+H”1).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,313339-35-4, 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; ABBOTT LABORATORIES; VASUDEVAN, Anil; PENNING, Thomas; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; WU, Fengchun; SHEN, Yan; LIU, Cuihua; ZOU, Zhenguang; WO2012/97478; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia