In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 49844-90-8, name is 4-Chloro-2-(methylthio)pyrimidine, the common compound, a new synthetic route is introduced below. Product Details of 49844-90-8
Indole I (400.88g) in 25OmL THF, 2L of IN K1BuO, and 381g pyrimidine II in 35OmL THF were combined with cooling to maintain under 40 0C and allowed to stir at r.t, for 1 hour. The solvent was then removed in vacuo and the solid was suspended in MeOH, filtered, washed with MeOH, water, and again with MeOH, to yield 87.56% III.
The synthetic route of 49844-90-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2009/138340; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia