Related Products of 23956-12-9, Adding some certain compound to certain chemical reactions, such as: 23956-12-9, name is 5-(2-Hydroxyethyl)pyrimidine-2,4(1H,3H)-dione,molecular formula is C6H8N2O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23956-12-9.
Mixture of 2 (2.75 g, 17.61 mmol) and acetic anhydride (14.1 mL, 0.15 mol) in anhydrous pyridine (25 mL) was refluxed for 1 h, then water (20 mL) was added and solvent was removed under reduced pressure. Co-evaporation of oily residue with toluene (2 x 30 mL) gave crude product which was purified by column chromatography (CH2Cl2 : CH3OH = 20 :1) to give white crystals of 4 (3.31 g, 95 %, m.p.= 205 – 207 C). 1H-NMR: 11.08 (1H, s, NH-3), 10.72 (1H, s, NH-1), 7.32 (1H, s, H-6), 4.07 (2H, t, J = 6.73 Hz, H-2′), 2.48 (2H, t, J = 6.69 Hz, H-1′), 1.99 (3H, s, CH3). 13C-NMR: 170.72 (C=O), 159.60 (C-4), 156.13 (C-2), 151.28 (C-6), 115.17 (C-5), 62.75 (C-2′), 24.32 (C-1′), 21.13 (CH3). ESI-MS 199 [M+H]+. Anal. calcd. For C8H10N2O4: C 48.48, H 5.09. Found: C 48.39, H 5.11.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 23956-12-9, 5-(2-Hydroxyethyl)pyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Kraljevi?, Tatjana Gazivoda; Klika, Mateja; Kralj, Marijeta; Martin-Kleiner, Irena; Jurmanovi?, Stella; Mili?, Astrid; Padovan, Jasna; Rai?-Mali?, Silvana; Bioorganic and Medicinal Chemistry Letters; vol. 22; 1; (2012); p. 308 – 312;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia