Analyzing the synthesis route of 5-Bromo-2,4-dichloropyrimidine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36082-50-5, 5-Bromo-2,4-dichloropyrimidine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 36082-50-5, 5-Bromo-2,4-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

To a stirred solution of 5-bromo-2,4-dichloropyrimidine (500 mg, 2.19 mmol) in MeOH (5 mL) was added a 30% solution of sodium methoxide (0.40 mL, 2.26 mmol). The reaction mixture was stirred at RT for 2 h then concentrated. The residue was dissolved in water (5 mL) and extracted with EA (3 x 5 mL). The combined organic layer was washed with brine, dried over MgS04 and concentrated to afford 432 mg (88%) of 5-bromo-2-chloro-4-methoxypyrimidine as white solid. LCMS- ESI (m/z) calculated for C5H4BrClN20: 223.4; found 224.2 [M+H]+, tR = 7.66 min. (Method 2).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36082-50-5, 5-Bromo-2,4-dichloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; RECEPTOS, INC.; BOEHM, Marcus, F.; MARTINBOROUGH, Esther; MOORJANI, Manisha; TAMIYA, Junko; HUANG, Liming; YEAGER, Adam, R.; BRAHMACHARY, Enugurthi; FOWLER, Thomas; NOVAK, Andrew; MEGHANI, Premji; KNAGGS, Michael; WO2013/90454; (2013); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia