Application of 56181-39-6, Adding some certain compound to certain chemical reactions, such as: 56181-39-6, name is 5-Bromo-4-chloropyrimidine,molecular formula is C4H2BrClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56181-39-6.
EXAMPLE 13: 5-bromo-N-(l-methylpiperidin-4-yl)pyridine-4-amine17To a stirred solution of 5-bromo-4-chloropyrimidine (300mg, 1.562mmol) in DMF, DIPEA (400mg, 3.124mmol) was added followed by l-methylpiperidine-4-amine (0.193ml, 1.562mmol) and the reaction mixture was heated at 80 C overnight. TLC showed absence SM, and then reaction mixture was concentrated. The crude product was purified by flash column chromatography over 230-400 mesh silica gel and using a mixture of 30% EtO Ac/petroleum ether to afford the desired product 17, 180mg (Yield: 40 %) as yellow solid. The product was confirmed by 1FiNMR and MS spectrum analysis. 1H NMR (400 MHz, CDC13) delta: 8.4 (s, 1H), 8.35 (s, 1H), 6.81 (d, 1H), 4.95 (m, 1H), 2.78 (d, 2H), 2.17 (s, 3H), 1.95 (t, 2H), 1.6-1.8 (m, 4H); MS- 270 (M+l).
According to the analysis of related databases, 56181-39-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ARRIEN PHARMAEUTICALS LLC; VANKAYALAPATI, Hariprasad; APPALANENI, Rajendra, P.; REDDY, Y., Venkata Krishna; WO2012/135631; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia