Related Products of 4319-87-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4319-87-3, name is 5-Bromo-4-methoxy-6-methylpyrimidine, molecular formula is C6H7BrN2O, molecular weight is 203.04, as common compound, the synthetic route is as follows.
A mixture of 4-[3-methyl-4-(4,4,5,5-tetram ethyl-i ,3,2-d ioxaborolan-2-yl)phenoxy]furo[3,2- c]pyridine (C2) (4.0 g, ii mmol), 5-bromo-4-methoxy-6-methylpyrimidine (Z. Wang et al., Synthesis2Oll, 1529-1531)(2.Og, 10 mmol), [1,1?-bis(diphenylphosphino)ferrocene]dichloropalladium(ll) (1.1 g, 1.4 mmol) and potassium carbonate (4.0 g, 29 mmol) in 1 ,4-dioxane (30 mL) containing 5 drops of water was heated at 120 00 for 2 hours. After filtration and concentration of the filtrate under reduced pressure, the residue was purified by silica gel chromatography (Eluent: 33% ethyl acetate in petroleum ether) to give the product as a yellow solid. Yield: 1.8 g, 5.2 mmol, 52%. 1H NMR (400 MHz, ODd3) oe8.72 (s, 1H), 8.07 (d, J=6.0 Hz, 1H), 7.66 (d, J=2.3 Hz, 1H), 7.25 (dd, J=5.9, 0.9 Hz, 1H), 7.19-7.21 (m, 1H), 7.09-7.16 (m, 2H), 6.88 (dd, J=2.3, 0.8 Hz, 1H), 3.95 (s, 3H), 2.29 (s, 3H), 2.07 (s,3H).
Statistics shows that 4319-87-3 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-4-methoxy-6-methylpyrimidine.
Reference:
Patent; PFIZER INC.; COE, Jotham, Wadsworth; ALLEN, John, Arthur; DAVOREN, Jennifer, Elizabeth; DOUNAY, Amy, Beth; EFREMOV, Ivan, Viktorovich; GRAY, David, Lawrence, Firman; GUILMETTE, Edward, Raymond; HARRIS, Anthony, Richard; HELAL, Christopher, John; HENDERSON, Jaclyn, Louise; MENTE, Scot, Richard; NASON, Deane, Milford, II; O’NEIL, Steven, Victor; SUBRAMANYAM, Chakrapani; XU, Wenjian; WO2014/72881; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
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