Adding a certain compound to certain chemical reactions, such as: 19808-30-1, 5-Bromopyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 19808-30-1, blongs to pyrimidines compound. Application In Synthesis of 5-Bromopyrimidin-4(3H)-one
EXAMPLE 12: 5-bromo-4-chloropyrimidine15 A stirred solution of 5-bromopyrimidin-4-ol (650mg, 3.73mmol) in POCI3 (in excess) was heated at 100C overnight. The reaction mixture was cooled and concentrated under reduced pressure. Crude product was dissolved in ethyl acetate and this mixture was slowly poured into saturated sodium bicarbonate solution. The ethyl acetate layer was separated and washed with brine solution, and dried over anhydrous sodium sulphate and concentrated to get the desired product 15 as yellow solid, 300mg (Yield- 43%). The product was confirmed by 1HNMR and MS spectrum analysis. 1H NMR (400 MHz, CDC13) delta: 8.86 (s, 1H), 8.82 (s, 1H); MS- 192 (M+l).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19808-30-1, its application will become more common.
Reference:
Patent; ARRIEN PHARMAEUTICALS LLC; VANKAYALAPATI, Hariprasad; APPALANENI, Rajendra, P.; REDDY, Y., Venkata Krishna; WO2012/135631; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia