Adding a certain compound to certain chemical reactions, such as: 28485-17-8, 5-Carbethoxyuracil, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H8N2O4, blongs to pyrimidines compound. Formula: C7H8N2O4
Step i. Ethyl 2,4-dichloropyrimidine-5-carboxylate Under an N2 atmosphere, a mixture of 5-carbethoxyuracil (1.0 g, 5.4 mmol) and POCl3 (10 mL) was heated at reflux for 30 minutes. The solution was concentrated under reduced pressure to remove the excess of POCl3, and the residue was poured into ice (20 g). CH2Cl2 (100 mL) was added, and the mixture was basified to pH 9 using saturated aqueous NaHCO3 solution. The organic portion was dried over MgSO4 and concentrated to obtain ethyl 2,4-dichloropyrimidine-5-carboxylate as a yellow oil (900 mg, 75%).
The synthetic route of 28485-17-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Martinborough, Esther; Zimmermann, Nicole; Perni, Robert B.; Arnost, Michael; Bandarage, Upul K.; Maltais, Francois; Bemis, Guy; US2006/160817; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia