Reference of 1993-63-1, Adding some certain compound to certain chemical reactions, such as: 1993-63-1, name is 5-Fluoro-2-methoxypyrimidin-4-amine,molecular formula is C5H6FN3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1993-63-1.
Take 27.2kg of Intermediate 5 prepared in the previous step and mix with sulfuric acid, raise the temperature to 95-105 C, maintain the temperature for 1.5h, and then lower the temperature. Then add the mixture to water, adjust the pH to 8-9, cool, and stand still. Set, filter, and dry to obtain 23.3 kg of crude product with a yield of 95.0%. Step 6: Take 20.5 kg of the crude product prepared in the previous step and mix it with 200 kg of water, add 0.6 kg of activated carbon, stir and raise the temperature, maintain the temperature for 1 h, and filter. The resulting mother liquor is cooled and crystallized, filtered, and dried to obtain 19.7 kg of 5-fluorocytosine. The yield is 96.1%, and the purity of HPLC is 99.9% or more. According to the reaction yield of each step, the total yield of the process route provided by the present invention is 57.3%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1993-63-1, 5-Fluoro-2-methoxypyrimidin-4-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Zhejiang Pioneer Technology Co., Ltd.; Gao Junlong; Gao Feifei; Li Ming; Chen Xiaoping; Wei Chenhui; (8 pag.)CN108033917; (2019); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia