Adding a certain compound to certain chemical reactions, such as: 51-20-7, 5-Bromouracil, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 51-20-7, blongs to pyrimidines compound. HPLC of Formula: C4H3BrN2O2
To 5-bromouracil (50 G) were sequentially added N, N-diethylaniline (60 mL) and phosphoryl chloride (120 mL), and the mixture was refluxed for 5 h. The volatiles were removed by distillation, the residue poured into ice water and the mixture extracted with methyl tert-butyl ether. The combined extracts were washed with brine, dried (NA2SO4) and filtered through Celite. Distillation of the crude product gave the title compound (63.4 g). IH NMR (300 MHz, CDCl3) : O/PPM = 8.69 (s, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,51-20-7, its application will become more common.
Reference:
Patent; SCHERING AKTIENGESELLSCHAFT; WO2004/48343; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia