Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine. A new synthetic method of this compound is introduced below., category: pyrimidines
Under an Ar gas atmosphere, the intermediate body X3 (4.8 g, 10 mmol), the intermediate body X7 (3.9 g, 10 mmol), an aqueous solution of 2M sodium carbonate (12 ml), toluene (20 ml), DME (20 ml) and Pd(PPh3)4 (0.35g) were stirred for 16 hours at a reflux temperature. After the reactant solution was cooled down to the room temperature, toluene (200 ml) and water (100 ml) were added thereto to separate an organic phase. The residue obtained by concentrating the organic phase was refined by silica-gel column chromatography (a developing solvent: hexane-toluene) and was recrystallized by toluene twice to provide a target object (a compound No. 4) as a white solid. A yield of the compound No. 4 was 2.6 g and a yield rate thereof was 35%. FD mass analysis consequently showed that m/e was equal to 741 while a calculated molecular weight was 741
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Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2489664; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia