Electric Literature of 2434-53-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2434-53-9, name is 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below.
General procedure: 7 (2.0 mmol, 0.38 g) and the corresponding amine (2.0 mmol) were placed in pressure tube under the flow of dry argon and dissolved in dry DMF (10 mL) containing 1 mL of TMSCl. The mixture was heated at 100 C during 2-12 h (controlled by TLC). Then this solution was evaporated under reduced pressure, treated with water, filtrated and dried on the air and recrystallized from an appropriate solvent, or was subjected to a column chromatography over silica gel.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2434-53-9, 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.
Reference:
Article; Iaroshenko, Viktor O.; Vilches-Herrera, Marcelo; Gevorgyan, Ashot; Mkrtchyan, Satenik; Arakelyan, Knar; Ostrovskyi, Dmytro; Abbasi, Muhammad S.A.; Supe, Linda; Hakobyan, Ani; Villinger, Alexander; Volochnyuk, Dmitriy M.; Tolmachev, Andrei; Tetrahedron; vol. 69; 3; (2013); p. 1217 – 1228;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia