In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 784150-41-0, name is 6-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine, the common compound, a new synthetic route is introduced below. Formula: C6H3BrClN3
A mixture of 6-bromo-4- chloro-7/-/-pyrrolo[2,3-c]pyrimidine (232 mg, 1 mmol), PhB(OH)2 (365 mg, 3 mmol), Cu(OAc)2 (363 mg, 2 mmol) and 1 , 10-phenanthroline (360 mg, 2 mmol) was stirred in DMF (20 mL) for 16 h before the reaction was diluted with saturated NH4CI(aq) (200 mL) and water (200 mL). The resulting mixture was extracted with EtOAc (3 x 50 mL), the combined organic phases were passed through a phase separator, concentrated in vacuo, and the residue was purified by flash chromatography (40 g GraceResolv silica, 0-60% EtOAc in cyclohexane) to give the title compound (170 mg, 55%) as colourless solid. LCMS (Method B): RT = 1.42 min, m/z = 308, 310, 312 [M+H]+.
The synthetic route of 784150-41-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ALMAC DISCOVERY LIMITED; O’DOWD, Colin; HARRISON, Tim; HEWITT, Peter; ROUNTREE, Shane; HUGUES, Miel; BURKAMP, Frank; JORDAN, Linda; HELM, Matthew; BROCCATELLI, Fabio; CRAWFORD, James John; GAZZARD, Lewis; WERTZ, Ingrid; LEE, Wendy; (304 pag.)WO2018/73602; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
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