Electric Literature of 31737-09-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 31737-09-4, name is 6-Chloro-1-methylpyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below.
Intermediate 49 was prepared from Intermediate 4 and Intermediate 46 by a method analogous to that of Step 1 of Example 1, Yield 81.8%. Step 1: Preparation of 1-(2-butyn-1-yl)-6-chloropyrimidine-2,4(1H,3H)-dione (Intermediate 1) 6-chlorouracil (14.5 g, 100 mmol) was dissolved in a mixed solution of 150 mL of N,N-dimethylformamide (DMF) / dimethylsulfoxide (DMSO) (VDMF / VDMSO = 6: 1), cooled to 0C, adding sodium hydride (4.2 g, 105 mmol). After stirring for 5 min, lithium bromide (13.0 g, 105 mmol) was added, stirring was continued for 15 min, then 1-bromo-2-butyne (14.0 g, 105 mmol) in N,N-dimethylformamide solution (50 mL) was added dropwise thereto, followed by stirring at room temperature for 10 to 12 hours. After completion of the reaction, the reaction solution was poured into ice water, and the precipitated solid was stirred, filtered and vacuum dried to obtain 17.0 g of a light yellow solid in a yield of 85.6%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,31737-09-4, its application will become more common.
Reference:
Patent; Qilu Pharmaceutical Co.,Ltd.; Chen, Dong; Fan, Chuanwen; He, Xujun; Cheng, Zhe; Li, Chenglong; (36 pag.)CN103848811; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia