Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4316-94-3, name is 6-Chloro-5-nitropyrimidin-4-amine. A new synthetic method of this compound is introduced below., Computed Properties of C4H3ClN4O2
4-Amino-5-nitro-6- chloropyrimidine (5.0 g, 29 mmol), 4-(l-aminoethyl)phenol (4.3 g, 32 mmol) and Et3N (4.5 mL, 3.2 g, 32 mmol) were combined in anhydrous DMF (30 mL). After stirring 2 h at 25 0C, the mixture was poured into dilute citric acid (150 mL; pH ca. 3) and the precipitated product was collected by suction filtration and washed with H2O. The solid was recrystallized from a refluxing mixture Of H2O (100 mL) and EtOH (50 mL) to yield 6.6 g (84%).
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Reference:
Patent; DOW AGROSCIENCES LLC; BREWSTER, William; DEMETER, David; ERICKSON, W.; LOWE, Christian; KLITTICH, Carla; NUGENT, Jaime; RIEDER, Brent; SIDDALL, Thomas; YAO, Chenglin; YERKES, Carla; ZHU, Yuanming; WO2011/25505; (2011); A1;,
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