Related Products of 4765-77-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4765-77-9, name is 6-Chloropyrimidin-4(1H)-one, molecular formula is C4H3ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 6-chloropyrimidin-4(3H)-one (50 mg, 0.383 mmol), 4-(2- hydroxy-2-methylpropoxy)-3 -methoxyphenylboronic acid Part D of Procedure 4 ( 184 mg, 0.766 mmol), copper (II) acetate, monohydrate (84 mg, 0.421 mmol), and pyridine (1.5 mL, 19.15 mmol) in DCM (4 mL) was stirred at RT under the presence of air overnight (21 hours). Pyridine (0.5 mL) and MeOH (0.5 mL) were added and continued to stir for 2 hours. The reaction was diluted with DCM, washed with IN HCl, sat NaHCO3, dried (Na2SO4), and concentrated to afford crude product. The crude was purified using ISCO flash chromatography (silica gel/hexanes -ethyl acetate 100:0 to 0: 100 gradient) to afford the desired product 6-chloro-3-(4-(2-hydroxy-2- methylpropoxy)-3-methoxyphenyl)-pyrimidin-4(3H)-one HA (57.4 mg, 0.177 mmol, 46 % yield) as a light brown solid.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4765-77-9, 6-Chloropyrimidin-4(1H)-one.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; AHMAD, Saleem; WO2010/104818; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia