Application of 6328-58-1, Adding some certain compound to certain chemical reactions, such as: 6328-58-1, name is 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one,molecular formula is C6H8N2OS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6328-58-1.
Propargyl bromide (2) (1.2 mmol, 0.10 mL) was added slowlyto a stirred mixture of 6-methyl-2-(methylthio)pyrimidine-4(3H)-one (1) (1.0 mmol, 0.15 g) and K2CO3 (2.0 mmol,0.27 g) in dry DMF (4 mL) at room temperature, and the mixturewas stirred at room temperature for 10 h. Upon completionof the reaction, the solvent was evaporated under vacuum,and the resulting residue was washed with water. The residuewas finally purified by flash column chromatography (hexane/ethyl acetate = 10:1) to give the titles compounds. Compound (3): TLC (hexane/ethyl acetate = 10:1)Rf = 0.7; yield 70%; white powder; m.p. 80-82 C; 1H NMR(300 MHz, CDCl3): delta 2.38 (s, 3H, CH3), 2.51 (t, J = 2.4 Hz,1H, CH), 2.56 (s, 3H, CH3), 5.00 (d, J = 2.4 Hz, 2H, CH2),6.30 (s, 1H, ArH); 13C NMR (75 MHz, CDCl3): delta 14.0,23.8, 53.6, 74.9, 78.1, 102.0, 167.9, 168.1, 171.3; IR (KBr):3167, 2925, 2116, 1581, 1404, 1339, 1041 cm-1. Anal.calcd for C9H10N2OS: C, 55.65; H, 5.19; N, 14.42; found:C, 55.82; H, 5.28; N, 14.58%.Compound (4): TLC (hexane/ethyl acetate = 10:1) Rf = 0.52;yield 30%; white powder; m.p. 122-124 C; 1H NMR(300 MHz, CDCl3): delta 2.15 (s, 3H, CH3), 2.20 (t, J = 2.4 Hz, 1H,CH), 2.53 (s, 3H, CH3), 4.76 (d, J = 2.4 Hz, 2H, CH2), 6.00(s, 1H, ArH); 13C NMR (75 MHz, CDCl3): delta 15.1, 23.8, 32.6,72.3, 107.6, 161.1, 161.3, 162.7; IR (KBr): 3124, 3001, 1645,1581, 1543, 1461 cm-1. Anal. calcd for C9H10N2OS: C, 55.65;H, 5.19; N, 14.42; found: C, 55.79; H, 5.11; N, 14.28%.
According to the analysis of related databases, 6328-58-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Rezaeimanesh, Fatemeh; Bakherad, Mohammad; Nasr-Isfahani, Hossein; Journal of Chemical Research; vol. 43; 9-10; (2019); p. 431 – 436;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia