Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6299-87-2, name is 6-Hydroxypyrimidine-4-carboxylic acid. A new synthetic method of this compound is introduced below., Application In Synthesis of 6-Hydroxypyrimidine-4-carboxylic acid
The 6-chloropyrimidine-4-carbonyl chloride used as a starting material was prepared as follows: Phosphorus oxychloride (10 ml) was added carefully to a stirred sample of 6-hydroxypyrimidine-4-carboxylic acid (1 g) and the mixture was heated to reflux for 16 hours. Phosphorus pentachloride (5.8 g) was added and the resultant mixture was heated to reflux for a further 16 hours. The excess of phosphorus oxychloride was evaporated under reduced pressure and the residue was distilled. A solid formed in the cooling condenser. There was thus obtained 6-chloropyrimidine-4-carboxylic acid (0.5 g); NMR (DMSOd6) 8.07 (s, 1H), 9.2 (s, 1H), 14.0-14.3 (br s, 1H).
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Reference:
Patent; Astra Zeneca AB; US6455520; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia