Related Products of 6693-08-9, Adding some certain compound to certain chemical reactions, such as: 6693-08-9, name is 2,4,6-Trichloro-5-fluoropyrimidine,molecular formula is C4Cl3FN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6693-08-9.
The thiophene (300 mg, 3.57 mmol) was dissolved in anhydrous tetrahydrofuran (20 mL).After cooling to -15 C, n-butyllithium (1.4 mL, 3.57 mmol, 2.5 mol/L) was added.Stir at this temperature for 1 hour, then add ZnCl2-TMEDA (300 mg,1.18 mmol), stirring at room temperature for 1 hour, then adding palladium dichloride (65 mg, 0.36 mmol),Triphenylphosphine (188 mg, 0.71 mmol)And 5-fluoro-2,4,6-trichloropyrimidine (790 mg, 3.92 mmol),The resulting mixture was heated to 55 C under nitrogen to stir the reaction overnight.Water (50 mL) was added to the reaction mixture, and the mixture was evaporated.The combined organic phases were washed with brine (50 mL).Dry over anhydrous sodium sulfate, filter and concentrate under reduced pressure.The residue obtained is purified by silica gel column chromatography (pure petroleum ether).The title compound was obtained as a white solid(366 mg, 41%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6693-08-9, 2,4,6-Trichloro-5-fluoropyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Tang Changhua; Yin Junjun; Yi Kai; Lei Yibo; Wang Yejun; Zhang Yingjun; (138 pag.)CN108276401; (2018); A;,
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