As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58347-49-2, name is 7-Chloropyrazolo[1,5-a]pyrimidine, molecular formula is C6H4ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 58347-49-2
EXAMPLE 46(S)-A- { 5,7-Difluoro-3 -[ 1 -(pyrazolof 1 ,5 -alpha]pyrimidin-7-ylamino)ethyllquinolin-2-yl} – piperazin-2-oneA solution of Intermediate 30 (61.2 mg, 0.20 mmol), 7-chloropyrazolo[l,5-alpha]- pyrimidine (33.8 mg, 0.2 mmol) and DIPEA (28.5 mg, 0.22 mmol) in M-BuOH (3 mL) was heated at 12O0C for 16 h. The solvent was removed in vacuo and the residue purified by preparative HPLC to afford the title compound (14.9 mg, 18%) as a cream solid. 6H (CDCl3) 8.45 (IH, s), 8.13 (IH, d, J5.2 Hz), 8.02 (IH, s), 7.35 (IH, dd, J 8.8 Hz), 6.90 (IH, t, J8.8 Hz), 6.88 (IH, d, J6.4 Hz), 6.55 (IH, br s), 6.48 (IH, s), 5.89 (IH, d, J5.2 Hz), 5.12-5.18 (IH, m), 4.09 (2H, q, J 17.5 Hz), 3.52-3.68 (4H, m), 1.88 (3H, d, J6.8 Hz). LCMS (ES+) 424 (M+H)+, RT 3.07 minutes {Method 1).
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Reference:
Patent; UCB PHARMA S.A.; ALLEN, Daniel, Rees; BROWN, Julien, Alistair; BUeRLI, Roland; HAUGHAN, Alan, Findlay; LANGHAM, Barry, John; MATTEUCCI, Mizio; OWENS, Andrew, Pate; RAPHY, Gilles; SHARPE, Andrew; WO2010/133836; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia