Analyzing the synthesis route of 7-Hydroxypyrazolo[4,3-d]pyrimidine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13877-55-9, 7-Hydroxypyrazolo[4,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Application of 13877-55-9, Adding some certain compound to certain chemical reactions, such as: 13877-55-9, name is 7-Hydroxypyrazolo[4,3-d]pyrimidine,molecular formula is C5H4N4O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13877-55-9.

Compound 28: DMF (1.05 mL) was added to a solution containing 27 (1.0 g, 7.3 mmol) in thionyl chloride (21 mL). Heated the stirring solution to 90 C. for 1 hour. Cooled the homogeneous reaction mixture to room temperature. Concentrated to remove volatiles and diluted the reaction mixture with EtOAc followed by ice. Extracted the aqueous layer with EtOAc. Combined the organics, washed with saturated NaHCO3, dried with MgSO4, filtered and concentrated to afford 28 (0.73 g, 64%), ES (+) MS m/e=155.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13877-55-9, 7-Hydroxypyrazolo[4,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sunesis Pharmaceuticals, Inc.; US2007/27166; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia